What is the Thyroid Gland?
A small gland located at the base of the throat, the thyroid contains the only cells
in the human body capable of absorbing and storing iodine. When optimally
functioning, it concentrates iodine from a person’s blood—obtained
through food or iodized salt—and combines it with the amino acid, Tyrosine.
This is then converted into the hormones that control a person’s metabolism
and growth rate.
What is ThyroSafe?
Manufactured by Astrea Fontaine SAS, France, who has more than 20 years experience
in manufacturing Potassium Iodide tablets. Thyrosafe was developed to protect the
thyroid against radioactive iodine released during a nuclear emergency.
How Does Radiation Affect Human Health?
During a nuclear emergency, radioactive iodine is released into the air. Once
swallowed or inhaled, it is then absorbed into the thyroid gland. Even the smallest
amount of radioactive iodine can result in abnormalities later in life, including
but not limited to: loss of thyroid functions, nodules in the thyroid, or thyroid
cancer. It is important to note that children are extremely susceptible to these
conditions due to their especially active thyroids.
For more information on Potassium Iodide from the FDA, visit https://www.fda.gov/drugs/bioterrorism-and-drug-preparedness/frequently-asked-questions-potassium-iodide-ki#Can%20KI%20be%20used
Why Use ThyroSafe?
ThyroSafe is a 65 mg KI Tablet that is FDA approved to help prevent radioactive
iodine from getting into the thyroid gland during a nuclear radiation emergency.
How Safe is ThyroSafe?
As reported in the American Journal of Medicine (Volume 94, P.524-532, May, 1993),
side effects among the roughly 18 million individuals who took Potassium Iodide (KI)
after the Chernobyl accident were minimal. Approximately 3% suffered some form of
upset stomach (due, in part, to a liquid KI being used instead of a tablet); 1%
developed a mild skin rash; and 1% suffered other mild symptoms. Only 2 cases of
more serious side effects were ever noted, and both occurred among people with known
allergies to iodide.
Is ThyroSafe Safe for Use During Pregnancy?
According to the FDA, pregnant women should be given potassium iodide (KI) for their
own protection and for that of the fetus as iodine (whether stable or radioactive)
can readily cross the placenta. However, because of the risk of blocking fetal
thyroid function with excess stable iodine, repeat dosing of KI should be avoided.
Who should not take ThyroSafe or have restricted use?
According to the FDA, individuals with known iodine sensitivity should avoid KI, as
should individuals with dermatitis herpetiformis and hypocomplementemic vasculitis,
extremely rare conditions associated with an increased risk of iodine
hypersensitivity. A seafood or shellfish allergy does not necessarily mean that an
individual is allergic or hypersensitive to iodine. Individuals with nodular thyroid
with heart disease should not take KI. Individuals with multinodular goiter,
Graves' disease, and autoimmune thyroiditis should be treated with caution --
especially if dosing extends beyond a few days. If you are not sure if you should
take KI, consult your healthcare professional.
When Should ThyroSafe Be Used?
ThyroSafe should be ingested as soon as possible following an alert from public
health officials. If health officials instruct you to repeat the dose, you should
take one dose every 24 hours. Do not take any other potassium iodide (KI)
products unless instructed to do so by authorities.
What is the recommended dose of Thyrosafe?
The FDA Guideline suggests, “For the sake of logistical simplicity in the
dispensing and administration of KI to children, we recommend a 65 mg dose as
standard for all school-age children, while allowing for the adult dose (130 mg, 2 x
65 mg.) in adolescents approaching adult size.
One of the major advantages of ThyroSafe is our standard cross-score, which makes it
easy to break into ½ or ¼ tablet to satisfy the graded dose
requirement, as recommended by the FDA Guideline (see below).
|THYROSAFE 65 MG TABLETS
|CHILDREN AGES 3 THROUGH 18 YRS
|CHILDREN OVER 1 MONTH THROUGH 3 YRS
For small children who cannot swallow the tablet with water, the required fraction
of tablet should be ground into a powder and then dissolved in water or other
preferable drink. For more information on treating infants, visit the U.S.
FDA’s discussion of the topic at:
Review the FDA Guidance
Will delayed use of ThyroSafe remove radioactive Iodine from the Thyroid?
Once it has penetrated the thyroid, radioactive iodine cannot be flushed out by a
subsequent administration of nonradioactive iodine. Therefore, any delay in
utilizing ThyroSafe is a serious risk, especially for children.